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Interestingly intermittent high doses of AKT
2024-05-18
Interestingly, intermittent high doses of AKT inhibitors have been shown to be a more effective strategy both clinically and pre-clinically. High doses appear to be required for induction of apoptosis and intermittent schedules overcome the low therapeutic index of these compounds. This is particula
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To verify whether circulating APN could protect
2024-05-18
To verify whether circulating APN could protect cognitive function during aging, we detected the alterations in circulating adipoenctin levels in aging rats. Our results suggested that circulating APN levels reduced with age. Kawasumi et al’s study results are consistent with ours. They concluded t
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Additionally regulation of GPCR heteromerization by specific
2024-05-18
Additionally, regulation of GPCR heteromerization by specific ligands may depend not only on the affinity of ligands for receptors, but also on presence of different interacting proteins co-localizing with the receptors in the specific cell, which may induce some conformational changes and contribut
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We also demonstrate that PACAP treatment
2024-05-18
We also demonstrate that PACAP treatment dose-dependently disrupts performance in the 5CSRTT, suggestive of attentional deficits, another core feature of mood and anxiety disorders. Treatment with PACAP (.5–1.0 µg) decreased the percentage of correct responses, increased the percentage of trials in
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angiotensin receptor blockers br Introduction Myasthenia gra
2024-05-18
Introduction Myasthenia gravis (MG) is an autoimmune disease characterised by failure of transmission at the neuromuscular junction (NMJ). In 80–85% of myasthenia gravis patients, the disease is mediated by antibodies to the nicotinic angiotensin receptor blockers receptor (AChR; (Lindstrom et al
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In earlier experiments on snails a behavioral
2024-05-18
In earlier experiments on snails, a behavioral model was employed of certain food rejection to study the mechanisms of the reconsolidation of long-term associative memory. It was found that conditioned food stimuli (reminder) presentation, combined with injections of NMDA glutamate receptor antagoni
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Introduction hydroxytryptamine HT is found throughout the
2024-05-18
Introduction 5-hydroxytryptamine (5-HT) is found throughout the body and influences smooth muscle activity in various tissues including the intestine, vasculature and urinary Cinacalcet HCl (Kim and Camilleri, 2000, Klarskov and Horby-Petersen, 1986, Mohammad-Zadeh et al., 2008). The current class
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br Funding br Introduction The interest in the
2024-05-18
Funding Introduction The interest in the effects of endocrine disrupting chemicals (EDCs) in the aquatic environment continues to increase over the past decade, specifically those that act on steroidogenic pathways. EDCs that include synthetic androgenic and estrogenic compounds can severely a
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br The cytochrome P enzyme hydroxylase lyase P
2024-05-18
The cytochrome P450 enzyme 17α-hydroxylase/17,20-lyase (P450) is involved in the production of the C containing androgen precursors from the C containing steroids such as the pregnanes and progestins (). Steroids such as androstenedione (AD) and dehydroepiandrosterone (DHEA) are therefore synthesi
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Various cardiovascular diseases show a high
2024-05-18
Various cardiovascular diseases show a high occurrence of autophagosomes. Whereas basal autophagy is required for the proper functioning of cardiomyocytes [82], the deletion of Atg5 gene in myocardium shows a high risk of cardiomyopathy [83]. Hamacher et al. observed that an upregulation of Bnip3, a
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The take home message here is that although
2024-05-18
The take-home message here is that, although Aurora A phosphorylated on T288 is the activated isoform of Aurora A, measuring the level of phosphorylation of T288 does not reflect Aurora A kinase activity (Figure 5). What would be the most appropriate readout for an in vivo Aurora A kinase activity
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The relative stereochemistry of both the
2024-05-18
The relative stereochemistry of both the major and minor diastereoisomer of (±)-2-(hydroxymethyl)blebbistatin (±)- (and thus (±)-2-(allyloxymethyl)blebbistatin (±)-) was determined with 1D-NOESY experiments (), as crystallization efforts failed. These experiments revealed an interaction between H an
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br Transparency document br Acknowledgments This work
2024-05-18
Transparency document Acknowledgments This work has been supported by the National Eye Institute (NIH) Grant 5R01EY023315-02 (MA). This study was also supported in part by National Center for Research Resources Grant S10RR027926 for the lipid analysis and by James and Jean Culver Vision Discov
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br Methods for antifungal testing of
2024-05-17
Methods for antifungal testing of mucorales species The Clinical and Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST) reference methods currently in place for in vitro antifungal susceptibility testing of filamentous fungi [8], [9] have
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br Concluding remarks Enhanced membrane
2024-05-17
Concluding remarks Enhanced membrane binding upon calcium stimulation in Z-LEHD-FMK suggests a pre-requisite step that involves a conformational change in LOX. This might facilitate it to tether to the membrane and regulate enzyme activity. The calcium binding loops and the putative active site