• VEGF inhibition causes vascular regression and tissue

  2020-06-30

  

  VEGF inhibition causes vascular regression and tissue hypoxia in tumor tissues and their surrounding healthy adipose tissues. In this regard, tumors in steatotic livers and adjacent to adipose tissues would experience more hypoxia than non-adipose tumors. Indeed, our present experimental results sup

• Where a a a and b b b

  2020-06-30

  

  Where a, a, a and b, b, b are respectively, repulsive friction constants and attraction friction constants. c represents the quadratic repulsive friction constant and P is critical pressure (bar). CPA equation of state CPA model is an EOS that simply combines a cubic EOS (SRK-EOS) and an associ

• As DNA methylation plays a critical

  2020-06-29

  

  As DNA methylation plays a critical role in organismic development and human diseases, the interest in DNA methyltransferases is constantly increasing. Extensive studies on the repertoires of dnmts genes have indicated increasing dnmts members in eukaryotes (Goll and Bestor, 2005; Ponger and Li, 200

• We recently reported that the

  2020-06-29

  

  We recently reported that the information about the electronic density obtained from a QTAIM analysis is useful to describe the molecular interactions that stabilize and destabilize the different complexes L-R [13], [14], [15]. Specifically in our previous work reported for DHFR inhibitors, the QTAI

• Hepatic steatosis is strongly associated with insulin resist

  2020-06-29

  

  Hepatic steatosis is strongly associated with insulin resistance. Numerous studies in humans and animals have shown that insulin-resistant states are often accompanied by hepatic steatosis (Angulo and Lindor, 2001, Marchesini et al., 1999, Marchesini et al., 2005, Petersen and Shulman, 2006, Seppala

• Overexpression of EP and DDR has

  2020-06-29

  

  Overexpression of EP300 and DDR1 has been sporadically reported in the pathogenesis of pulmonary fibrosis and other fibrotic diseases. Zeng et al. reported that EP300 was increased in TGF-β1 treated lung fibroblasts and mediated decreases of SIRT1 expression. Bhattacharyya et al. found that both EP3

• br Funding This work was

  2020-06-29

  

  Funding This work was supported by grants to A.S. from the Swedish Cancer Foundation, Sweden (Grant number: CAN, 2015/637), the Swedish Medical Council, Sweden (Grant number: 2017- 01274), the Foundations at Skåne University Hospital, Sweden and to KB, SRS, NC, BCS, and SS from the Royal Physiogr

• A cocktail approach can detect the activities

  2020-06-29

  

  A cocktail approach can detect the activities of multiple CYP 450 isoforms following administration of multiple CYP-specific substrates in a single experiment. Caffeine, losartan, omeprazole, dextromethorphan and midazolam are often used as substrates in “cocktail probes” of human cytochrome CYP1A2,

• Etoposide The radial distribution function is given by

  2020-06-29

  

  The radial distribution function, , is given by: For pure components and pseudo-components, the constants a and b are calculated as:whereand Tc, Pc and ω are the critical temperature, critical pressure and acentric factor, respectively. Parameters a and b for mixtures are calculated from those of

• The small molecule d mannuronic acid M patented DE

  2020-06-29

  

  The small molecule β-d-mannuronic Antagonist G (M2000), patented (DE-102016113018.4), has been tested as an anti-inflammatory and a novel immunosuppressive agent in various experimental models such as animal models of immune complex glomerulonephritis, nephrotic syndrome, multiple sclerosis and rheu

• Using characteristic features of ECM proteins and

  2020-06-29

  

  Using characteristic features of ECM proteins and a computational pipeline combining interrogation of protein and gene databases, we previously defined the matrisome as the ensemble of ECM and ECM-associated proteins [[16], [17], [18]]. In mammals, the matrisome represents 4% of the genome, or appro

• Although the analysis described above goes far to explain

  2020-06-29

  

  Although the analysis described above goes far to explain the mechanism of RF 9 perturbations through CHK1 inhibition, it raises important questions about the mechanism by which WT RAS isoforms promote CHK1 S280 phosphorylation. Previous reports have shown that both the MAPK-RSK and PI3K-AKT pathwa

• br Method Detailed study protocol was reported previously

  2020-06-29

  

  Method Detailed study protocol was reported previously. The ULTIMATE- HFrEF trial was approved by the Institutional Review Board of our hospital, and the study drug, udenafil, was approved as Investigational New Drug for treatment in patients with chronic HFrEF by Ministry of Food and Drug Safety

• EBI and its ligand s EBI was found in

  2020-06-29

  

  EBI2 and its ligand(s) EBI2 was found in a screen of upregulated genes in human B cells upon infection with EBV [1]. EBI2 is a G-protein (Gαi type) coupled receptor [2] but as long as 18 years after its discovery the nature of its ligand remained undisclosed. With the help of transfected cell lines

• Contrary to the downregulation of S PR family GPCRs

  2020-06-29

  

  Contrary to the downregulation of S1PR family GPCRs, CLL cells have increased mRNA expression of the lysophosphatidic carbenoxolone (LPA) family receptors LPAR1, LPAR3 and LPAR4 compared to normal B cells [47]. Increased LPAR1 mRNA has been shown to be associated with more aggressive disease [47] a

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