• br GPR is a class A GPCR expressed on pancreatic

  2022-07-13

  

  GPR119 is a class A GPCR expressed on pancreatic β-cells and certain enteroendocrine PNU 37883 hydrochloride which upon activation with an agonist, increases insulin secretion in response to rising glucose levels. Mechanistically, this insulinotropic effect is bifurcated involving both GPR119-med

• br Introduction Adipose tissue AT in addition to its

  2022-07-13

  

  Introduction Adipose tissue (AT), in addition to its function as CP-809101 hydrochloride storage, is an important endocrine organ and it secretes adipokines (Ahima, 2006). Adipose tissue is related to different physiological processes such as energy metabolism, insulin sensitivity, and inflammat

• Introduction Nicotinic acid niacin NA has been used in the

  2022-07-13

  

  Introduction Nicotinic ghrelin receptor antagonist (niacin, NA) has been used in the treatment of dislipidemia and cardiovascular disease for almost 60years (Offermanns, 2006). Large clinical studies showed that niacin alone or in combination with LDL-lowering drugs improved cardiovascular outcome

• br Results br Discussion Cell contact mediated spread of

  2022-07-13

  

  Results Discussion Cell-contact-mediated spread of HIV-1 has been estimated to be at least an order of magnitude more efficient compared to passive dissemination of particles through the extracellular milieu. Thus, this form of viral transmission can have significant effects on the pathogenesi

• Previously we have shown that rapid

  2022-07-13

  

  Previously, we have shown that rapid action of E2in vitro is mediated through two E2 membrane receptors, GPR30 (GPER1) and the STX-sensitive membrane receptors (Noel et al., 2008; Kenealy et al., 2011a, Kenealy et al., 2011b). This is significantly different from receptors implicated in the positive

• br The methyl aspartate receptor NMDAr hypofunction hypothes

  2022-07-13

  

  The -methyl--aspartate receptor (NMDAr) hypofunction hypothesis of schizophrenia correlates disease symptomology with glutamatergic neurotransmission dysfunction., , , Therefore, inhibition of glycine transporter 1 (GlyT1) to elevate synaptic levels of glycine and potentiate NMDAr signaling is a

• Axons are the largest component of WM by volume and

  2022-07-13

  

  Axons are the largest component of WM by volume and are a significant repository of intracellular glutamate that can be releases under ischemic conditions [1,3,4,29,117]. We have recently shown that the principle route by which mature myelinated CGRP (rat) synthesis release glutamate during acute i

• ABT 702 dihydrochloride australia A number of models have be

  2022-07-13

  

  A number of models have been proposed in order to explain the mechanisms of protein transport through nuclear pore complexes. One theory is that the transport is mediated by specific peptide signals known as NLSs. The classical NLSs are short sequences containing a high proportion of the positively

• Gli signaling pathways play critical roles in embryonic and

  2022-07-13

  

  Gli signaling pathways play critical roles in embryonic and postnatal lung development [22]. Many reports suggest that wound healing and fibrotic diseases involve activation of pathways used during development [23]. In the adult lung, Gli signaling activity measured by Gli1 expression is restricted

• Cartilage and subchondral bone synovial tissue interactions

  2022-07-13

  

  Cartilage and subchondral bone/synovial tissue interactions are well-recognized features of joint failure and osteoarthritis[17](seeFig. 1A, B). The intimate mechanical and biological interactions between these tissues are likely to alter the structural organization and function of either tissue. Ho

• Iodination of commercially available with excess

  2022-07-13

  

  Iodination of commercially available with excess ICl in AcOH gave a quantitative yield of , which was cyclized with benzyl thioamides to give the 2-benzyl-9,10-dihydro-4-1-thia-3,4-diaza-benzo[]azulenes . Coupling of the iodides with heterocycles including imidazoles, triazoles, or zinc cyanide us

• br Acknowledgement This work was

  2022-07-12

  

  Acknowledgement This work was supported by National Science Foundation (21475047, 21705051, 21874048), the Science and Technology Planning Project of Guangdong Province (2016B030303010), the Program for the Top Young Innovative Talents of Guangdong Province (2016TQ03N305) and the Foundation for H

• Based on the previous report that FXR regulated PEPCK

  2022-07-12

  

  Based on the previous report that FXR regulated PEPCK indirectly [20], we speculated that FXR may regulate gluconeogenesis by regulating some key transcription factors associated with gluconeogenesis. Finally, by using HS218 as a probe, we found that FXR binds to PGC-1α promoter and directly regulat

• Binding of FGFs to FGFRs leads to

  2022-07-12

  

  Binding of FGFs to FGFRs leads to receptor dimerization, resulting in the transphosphorylation of a tyrosine in the activation loop of the kinase domain. Subsequently, the activated FGFRs phosphorylate their intracellular receptor substrates, particularly FGFR substrate 2 (FRS2) and phospholipase Cγ

• aa utp sale Compared to a large database of NSCLC samples ma

  2022-07-12

  

  Compared to a large database of NSCLC samples matched for disease type, many of the frequently altered genes were similar to those seen in this series of FGFR fusion-positive samples; however, there were notable exceptions. As expected, alterations in known NSCLC drivers (KRAS and EGFR) were signifi

15978 records 400/1066 page Previous Next First page 上5页 396397398399400 下5页 Last page