calpain inhibitor The inhibition of differentiation has been

2018-10-20

The inhibition of differentiation has been considered to play a role in many types of tumor development through maintenance of the proliferating progenitor cell state. Previous studies demonstrated that the knockdown of EWS-FLI1 in Ewing sarcoma cell lines results in osteogenic, adipogenic and chond

br Experimental Procedures br Author

2018-10-20

Experimental Procedures Author Contributions Acknowledgments We thank Cory Abate-Shen, Maho Shibata, and Flaminia Talos for insightful comments on the manuscript. This work was supported by NIHR01DK076602. A.M. and R.T. were supported by post-doctoral fellowships from the DOD Prostate Cance

The mouse intestinal epithelium is

2018-10-20

The mouse intestinal epithelium is renewed through intestinal stem cells (ISCs) every 3–4 days (Barker, 2014). The “stem cell zone” model identifying crypt purchase AICAR columnar (CBC) cells at the base of the intestinal crypt (Cheng and Leblond, 1974) and “+4 stem cell” model identifying a ring o

Flow cytometry analysis showed that

2018-10-20

Flow cytometry analysis showed that independent targeted clones expressed remarkably similar levels of the inserted reporter genes, highlighting the consistency of expression produced by this vector configuration (Figure 1C). This consistency also enabled us to conclude that all the selectable mark

endothelin receptor br Experimental Procedures br Author Con

2018-10-20

Experimental Procedures Author Contributions Acknowledgments Our thanks go to Gioia Polidori Francisco for training and discussions, Kate Watt and Yvonne Turnbull for technical and laboratory managerial support, Kadri Oras and Laura Ferguson for experimental support, Po-Lin So and Bruce Con

br Results br Discussion In the present study we

2018-10-20

Results Discussion In the present study, we have shown that HPCA is an important regulator of the neuronal differentiation of NSCs and that it promotes neurogenesis and inhibits gliogenesis. HPCA expression markedly increased during differentiation of NSCs isolated from the cerebral cortex in

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2018-07-29