• With regard to the DGATs we have found

  2019-10-03

  

  With regard to the DGATs, we have found that the majority of algal species encode at least one DGAT1, although it appears to be absent from Ostreococcus and Micromonas, as is the case for yeast, S. cerevisiae. More surprising is the presence of multiple DGAT2 genes in algae, with the exception of C.

• DAPK is a kD Ca calmodulin CaM

  2019-10-03

  

  DAPK is a 160-kD Ca2+/calmodulin (CaM)-regulated Ser/Thr kinase that mediates cell death. The activated forms of DAPK and DRP-1 are capable of inducing two distinct cytoplasmic events characteristic of programmed cell death, including membrane blebbing and the formation of autophagic vesicles (Inbal

• br Conclusions br Declaration of interest br Acknowledgement

  2019-10-02

  

  Conclusions Declaration of interest Acknowledgements Introduction Uncorrected obesity has been a major health problem and the prevalence of obesity is fast rising reaching an epidemic proportion [[1], [2], [3]]. Ample of clinical and experimental evidence has suggested that obesity leads

• Neuronal cells have highly developed ER which makes

  2019-10-02

  

  Neuronal CP 154526 have highly developed ER, which makes them susceptible to loss of ER function following exposure to various agents, which leads to apoptosis (Lindholm et al., 2006, Katayama et al., 2004). Multiple pathways may be involved in ER stress-initiated apoptosis. Among them, the PKR-lik

• Our studies approached this problem using integrative

  2019-10-02

  

  Our studies approached this problem using integrative -omics analysis of human NK-ieILC1s from distinct microenvironments and functional subsets, including helper and adaptive phenotypes. At both the transcriptional and epigenetic levels, we find that the adaptive subset, CD57+ cytotoxic NK cells, s

• While a number of studies have helped elucidate the principl

  2019-10-02

  

  While a number of studies have helped elucidate the principles of target amino group specificity, UBL selectivity, and Ub topoisomerase inhibitors specificity [3], [4], [9], [10], [14], [19], [20], [23], [24], [33], [34], [37], [38], [39], [40], [41], the role of the canonical E2-RING interface in

• We have compared the potency

  2019-10-02

  

  We have compared the potency of a series of DNA-directed alkylating agents, including N-mustard-acridine, N-mustard-quinoline, and N-mustard-quinazoline conjugates previously synthesized in our laboratory [7], [13], and currently used drugs (oxaliplatin, cisplatin, or 5-FU) for the treatment of CRC

• br Conflicts of interest br Introduction Diacylglycerols DAG

  2019-10-02

  

  Conflicts of interest Introduction Diacylglycerols (DAGs) and phosphatidic Aminoallyl-dUTP kinase (PA) play fundamental roles in biology as basic components of membranes, intermediates in lipid metabolism, and secondary messengers in cellular signaling (Carrasco and Merida, 2007, Fang et al.,

• In conclusion over expression of Stokesia epoxygenase SlEPX

  2019-10-02

  

  In conclusion, over-expression of Stokesia epoxygenase (SlEPX) in soybean seeds led to some unusual seed phenotypes. These effects can be overcome by coexpression of Vernonia DGATs (VgDGAT1 & 2). The DGATs can specifically transfer vernolic 3\'-O-(2-nitrobenzyl)-2\'-dATP mass into TAG, largely redu

• br Acknowledgements The study was supported by grant no

  2019-10-02

  

  Acknowledgements The study was supported by grant no. 501-003-11043 from the Institute of Psychiatry and Neurology in Warsaw. The authors thank Mrs. Ala Biegaj for the excellent technical assistance. Introduction In an effort to identify hIFN receptor molecules encoded by a gene(s) within hum

• Physiological changes induced by CRF are mediated

  2019-10-02

  

  Physiological changes induced by CRF are mediated through CRF1 and CRF2 receptors (Chang et al., 1993, Lovenberg et al., 1995). Previous findings with CRF1 receptor antagonists showed that activation of CRF1 receptor is involved in maternal separation-induced ultrasonic vocalizations (Kehne et al.,

• Another option is to use the thiol groups of cysteine

  2019-10-02

  

  Another option is to use the thiol groups of cysteine residues, which can be modified by use of PEG-maleimide and vinyl sulfone. However, changes in PEGylation interactions or reaction conditions can result in changes in the functional properties of the therapeutic proteins [[50], [51], [52]]. A st

• Materials and methods br Results br Discussion Microbial pro

  2019-10-02

  

  Materials and methods Results Discussion Microbial production of trans-4Hyp, an added-value amino monobenzone and for pharmaceuticals, offers significant advantages over conventional chemical extraction in economic and environmental aspects. However the low titer and productivity with the exi

• There is a considerable molecular genetic heterogeneity

  2019-10-02

  

  There is a considerable molecular genetic heterogeneity within ES/PNET. As mentioned above, either or can rearrange with in these gene fusions. Furthermore, for either gene fusion, additional heterogeneity stems from the location of the genomic breakpoints of the translocation, resulting in diffe

• The indigenous populations living at high mountain regions o

  2019-10-02

  

  The indigenous populations living at high mountain regions of the Himalayas represent successful human (S)-Methylisothiourea sulfate to hypoxia. These populations have undergone selective positive natural selection over millennia across several genomic loci and exhibit unique respiratory, cardiopul

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