• V ATPase is a complex enzyme that is

  2024-09-26

  

  V-ATPase is a complex enzyme that is composed of several subunits, which are assembled into two domains: trans-membrane (V0) and cytosolic (V1) domains [3,5]. Epididymal epithelial Methimazole of rats has been reported to contain V-ATPase which is distributed at the apical pole of the narrow and cl

• The ambiguity surrounding the role played by

  2024-09-25

  

  The ambiguity surrounding the role played by the 15-LOXs in malignant biological processes stems also from the limitations of current animal models, and especially the usage of its 12/15-LOX murine homolog, which can also catalyze the production of 12-HETE. Indeed, the proinflammatory effect of 12-H

• GABAB receptor is associated with brain and

  2024-09-25

  

  GABAB receptor is associated with focus on  and behavioral diseases, including epilepsy, spasticity, anxiety and neuropathic pain (Bettler et al., 2004, Bowery et al., 2002, Froestl, 2010). Baclofen, a clinical drug and selective GABAB receptor agonist, is used to treat muscle spasticity in patient

• Furthermore we also found that the

  2024-09-25

  

  Furthermore, we also found that the basic level of ROS was markedly lower in mtDNA-reduced SW480 p-gp inhibitors than that in the parent cells. Endogenous ROS is most notably produced at the sites of complex I and complex III [5], it might be plausible that the decreased quantity of ROS observed in

• The mitochondrial protein AIF was the

  2024-09-25

  

  The mitochondrial protein AIF was the first caspase-independent death effector. AIF can induce caspase-independent chromatin condensation and large-scale DNA fragmentation to approximately 50 KB. AIF that is released to cytoplasm can mediate apoptosis when special extracellular signals trigger the o

• Since immunoassays cannot specifically quantify each apelin

  2024-09-25

  

  Since immunoassays cannot specifically quantify each apelin peptide, a more reliable approach, mass spectrometry (MS) has been used recently to quantify and characterize apelin fragments in plasma. Using this technology, Zhen et al. showed that [Pyr-1]-apelin-13 was the major apelin form present in

• In our study caspase and DRAM were

  2024-09-25

  

  In our study, caspase3 and DRAM were identified as being involved in full-length AIFM1-induced apoptosis. Caspase3 is best known for its role in the execution phase of apoptosis in both intrinsic and extrinsic apoptotic pathways [17]. The members of the caspase family are generally in inactive pro-f

• br Introduction O Dowd et al identified a gene

  2024-09-25

  

  Introduction O’Dowd et al. identified a gene very similar to angiotensin type-1 receptor in 1993 (O’Dowd et al., 1993). The specific selective ligand of this receptor called APJ receptor was determined by Tatemoto et al. in 1998 as apelin (Tatemoto et al., 1998). The high expression of apelin and

• It has been well established that

  2024-09-25

  

  It has been well established that shortly after systemic inflammation, NADPH oxidase and iNOS activity were increased in the Hexa His tag and lead to overproduction of reactive oxygen species (ROS) and NO [66]. Moreover, previous studies indicated that Ang II induced an increased level of NADPH oxi

• tbtu br Conclusions Our study confirms that N

  2024-09-25

  

  Conclusions Our study confirms that N-terminal mutations can affect Aβ fibril and oligomer formation, despite lying outside the core amyloid region of Aβ. Of the three factors that may influence Aβ-mediated toxicity (primary structure of Aβ, assembly structure and cellular responses), our results

• br Introduction There are greater than five

  2024-09-25

  

  Introduction There are greater than five million Americans living with Alzheimer's dementia and more than 35 million people worldwide [1], and without a way to stop or slow the progression, there will be nearly a tripling of individuals affected by 2050 (13.8 million) [1]. The urgency to develop

• The relatively high concentration of HT used in this study

  2024-09-25

  

  The relatively high concentration of 5-HT used in this study (100 µM) is consistent with the concentrations used in other published ex vivo studies (Ropert and Guy, 1991, Passani et al., 1994, Shen and Andrade, 1998). In our paradigm 5-HT was focally applied at the surface of the slice via a fast pe

• U 46619 The reductase family is composed of three known isoz

  2024-09-24

  

  The 5α-reductase family is composed of three known isozymes, with the types I and II being the most known. Type I isozyme, which is the dominant form, can be found in the skin, liver, kidney, brain and lung. Furthermore, it has been evidenced that type I activity is several times higher in PC than i

• During preparation of this manuscript some studies investiga

  2024-09-24

  

  During preparation of this manuscript, some studies investigating effects of Sunitinib on Axl activity in renal cancer have been published [44], [45], [46], [47]. However, there are several important considerations to take into account interpreting results of these studies. First, Sunitinib doses t

• The present study indicates elevated ATX

  2024-09-24

  

  The present study indicates elevated ATX activity as a highly sensitive and specific biomarker to differentiate ICP from other pregnancy-related liver disorders or pruritic dermatoses. In 1,2-Dilauroyl-sn-glycerol receptor to the current gold standard for diagnosis, total fasting serum bile salt le

15920 records 83/1062 page Previous Next First page 上5页 8182838485 下5页 Last page