• The crystal structure of the B

  2020-09-14

  

  The crystal structure of the B. subtilis Maf (BSU28050) was published in 2000, and, to date, it represents the only experimental work with a purified Maf protein (Minasov et al., 2000). The structure revealed a structural fold similar to that found in ITPases and YjjX proteins, which are nucleotide

• Atg cleaves Atg at the peptide bond on

  2020-09-14

  

  Atg4 cleaves Atg8 at the peptide bond on the glycine residue at the C-terminus, thus allowing the conjugation of Atg8 to phosphatidylethanolamine (PE) with the participation of other autophagy molecules. Atg4 can also serve as a deconjugating enzyme, which cleaves the amide bond of the conjugated At

• Interaction between neutrophils and ECs represents the first

  2020-09-14

  

  Interaction between neutrophils and ECs represents the first step of the cellular phase of the inflammatory response, and provide the best condition for the transfer of the PMNL-derived LTA4 to the ECs, leading to the transcellular formation of cysteinyl-LTs. It is intriguing therefore to think that

• br Conflict of interest statement br

  2020-09-14

  

  Conflict of interest statement Acknowledgement The study was financially supported by the Ministry of Education, Youth and Sports of the Czech Republic – projects “CENAKVA” (No. CZ.1.05/2.1.00/01.0024) and “CENAKVA II” (No. LO1205 under the NPU I program), by the Grant Agency of the University

• Additionally of outmost important is the location

  2020-09-14

  

  Additionally, of outmost important is the location of the different CpG islands in relation to the transcription starting site (TSS) of the promoter as well as their interaction with transcription activators or repressors. It has been shown that methylation at the downstream region of the TSS in the

• br Conclusion and future perspectives LDL cholesterol loweri

  2020-09-11

  

  Conclusion and future perspectives LDL cholesterol-lowering therapy is essential for cardiovascular risk reduction. On the background of a high inter-personal variation of cholesterol synthesis and cholesterol DTP3 the efficacy of cholesterol lowering, both, with statins and with ezetimibe exhib

• br Introduction Estrogens play an important role in the

  2020-09-11

  

  Introduction Estrogens play an important role in the DIDS mg (Arevalo et al., 2015). During several decades, estrogen withdrawal in women has been associated with cognitive impairment, increased Alzheimer\'s disease (AD) risk (Pike, 2017) and with psychiatric disorders such as schizophrenia (Kul

• In rodent models the loss of estrogens through ovariectomy

  2020-09-11

  

  In rodent models, the loss of estrogens through ovariectomy has been shown to promote the development of intracranial aneurysms. Conversely, the administration of an CGRP (rat) receptor beta agonist restores its protective effect, but is abolished with the introduction of a nitric oxide synthase inh

• In humans the ER is

  2020-09-11

  

  In humans, the ERα is encoded by the gene ESR1, located on chromosome 6, locus 6q25.1 (Gosden, Middleton, & Rout, 1986). In addition to the full-length ERα isoform (66kDa), several shorter isoforms (36kDa, 46kDa) have been identified as a result of the presence of alternate start codons, or as produ

• The new ESC guidelines incorporate data from a network meta

  2020-09-11

  

  The new ESC guidelines incorporate data from a network meta-analysis of 100 studies confirming that new-generation drug-eluting stents (DES) improve survival compared with medical treatment, although this has not been demonstrated in any individual study. REVASCULARIZATION IN NON–ST-ELEVATION ACU

• Studies of Jelski and Szmitkowski show that differences

  2020-09-10

  

  Studies of Jelski and Szmitkowski show that differences of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) activity between Murine of many cancers and healthy tissue may be one of the factors intensifying carcinogenesis [7]. Moreover, changes of ADH and ALDH activity in cancer cells a

• In this review focusing on biocatalyst formate

  2020-09-10

  

  In this review, focusing on biocatalyst “formate dehydrogenase FDH” catalyzing both of the formic Ketorolac tromethamine salt synthesis oxidation to CO2 and the CO2 reduction to formic acid, representative examples of properties, types, structure of active-site of FDH and, reaction mechanism of fo

• zingerone Asteroids can provide an abundant supply of other

  2020-09-10

  

  Asteroids can provide an abundant supply of other resources, such as carbon, nitrogen, or calcium compounds, but will only be useful once the space economy is sufficiently developed to provide economically interesting uses for them. Others, such as titanium or aluminium, also exist in asteroids, but

• In humans individual differences in prefrontal dopamine are

  2020-09-10

  

  In humans, individual differences in prefrontal dopamine are partially caused by the Val158Met single-nucleotide polymorphism on the catechol-O-methyltransferase gene (COMT). This gene controls activity of the COMT enzyme, which degrades extracellular catecholamines including dopamine. The Val varia

• We found that E and

  2020-09-10

  

  We found that E2 and GEN each has mostly similar effects on recruitment of the epigenetic modulators to the MB-COMT distal promoter (summarized in Table 2). These effects are associated with increased promoter methylation and gene suppression of COMT. It is noted that the array of epigenetic modulat

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