• The ongoing efforts to identify targeted therapy for

  2018-11-05

  

  The ongoing efforts to identify targeted therapy for dedifferentiated, metastatic PTC has led to empirically driven clinical trials of different tyrosine kinase receptor inhibitors that disrupt MEK, VEGFR, FGFR and other signaling pathways. These therapies were intended to slow disease progression,

• br Materials and methods br Results

  2018-11-05

  

  Materials and methods Results and discussion Conclusion An RSM based on CCRD and a multi-layer neural network (4-5-1 ANN architecture) models were developed in order to justify the aim of the current research. The input variables were temperature, time, volume of solvent, and particle size,

• The etiology was considered idiopathic in all cases

  2018-11-05

  

  The etiology was considered idiopathic in all cases, based on the high number of complementary exams performed. In the 6 cases in whom the anti-streptolysin-O levels was obtained, only one demonstrated a mildly high level, which does not support the hypothesis of streptococcal infection as a main tr

• A detailed analysis of hypocretinergic neuronal activity

  2018-11-05

  

  A detailed analysis of hypocretinergic neuronal activity shows that these neurons are strongly activated when animals are exploring an unknown environment (exploratory motor activity) [50]. In fact, in this study, the number of Hcrt+Fos+neurons was approximately 10 times greater during exploratory m

• While obesity maintained an intense association in the bivar

  2018-11-05

  

  While obesity maintained an intense association in the bivariate analysis (OR: 9.29), this association was lost in the multivariate analysis, where it was adjusted by neck circumference, which maintained a significant association. This is consistent with the results obtained by Preis et al. [26] in

• Our results are in accordance with

  2018-11-03

  

  Our results are in accordance with recent studies using RT combined with mAb-mediated blockade of PD-1 or PD-L1 in mouse models of melanoma (Sharabi et al., 2015), breast carcinoma (Deng et al., 2014; Sharabi et al., 2015), colon adenocarcinoma (Deng et al., 2014), glioma (Zeng et al., 2013) and mul

• We have also observed that elevated Glut on monocytes is

  2018-11-03

  

  We have also observed that elevated Glut1 on monocytes is associated with high sCD163 plasma levels within this HIV+ population, supporting a model by which chronic HIV infection drives metabolic activation of monocytes in response to inflammatory changes. This results from metabolic reprogramming w

• br Acknowledgments This work has been supported by the

  2018-11-03

  

  Acknowledgments This work has been supported by the California Institute for Telecommunications and Information Technology (CALIT2) under Grant number 2014CSRO 136. Experimental design, materials and methods Acknowledgments This work has been supported by the California Institute for Telec

• br Acknowledgements We are indebted to

  2018-11-03

  

  Acknowledgements We are indebted to K. Basler, S. Bray, M. Freeman E. Martín-Blanco and F. Schweisguth for fly lines. Some antisera used in this work were obtained from the Developmental Studies Hybridoma Bank (DSHB) developed under the auspices of the NICHD and maintained by the University of Io

• orthopox Several iterations of the OSC were tested before ar

  2018-11-03

  

  Several iterations of the OSC were tested before arriving at the design used in this article and the main research article [1]. The electrical design can be seen in Fig. 3. A custom PCB with the form factor of an Arduino shield was produced from the design seen in Fig. 4. The OSC has three main se

• We examined fcMRI network changes between and months of age

  2018-11-03

  

  We examined fcMRI network changes between 6 and 12 months of age in 92 infants of whom 36 infants had both 6 and 12 month scans (128 total datasets). The current fMRI data preprocessing strategy incorporates several recent advances that minimize the impact of head motion artifact more effectively th

• Motivations for investigating how sleep affects the large

  2018-11-03

  

  Motivations for investigating how sleep affects the large-scale default mode network (DMN) include: (1) reduced DMN connectivity has been linked to increased impulsivity in children (Inuggi et al., 2014); (2) the DMN undergoes considerable development during adolescence (Fair et al., 2008; Sherman e

• br Mechanism of the regulation of melanocyte function by ker

  2018-11-03

  

  Mechanism of the regulation of melanocyte function by keratinocytes To understand the mechanism of the regulation of melanocyte function by keratinocytes, analysis by a co-culture system of melanocytes and keratinocytes is useful. For the co-culture of melanocytes and keratinocytes, pure culture

• El acoso contra la atleta es

  2018-11-03

  

  El acoso contra la atleta es brutal. Ella no se cansa de declarar que es mujer ante las instituciones deportivas. Incluso después de reprobar la insiste en que es una mujer y así fue criada (: 316). Hay quienes opinan que la la regó en casi todos los giros del caso. La joven tuvo incluso que esconde

• Sobre su cuerpo reca a as el peso de la

  2018-11-03

  

  Sobre su cuerpo recaía así el peso de la ley: clínicamente, Guadalupe Vargas podía ser apta para el acto del coito, pero, por tener una sexualidad ambigua, el matrimonio le estaba prohibido: “[e]l doble eunuquismo purchase RepSox que la naturaleza condena a los hermafroditas (salvo una que otra rarí

15910 records 1046/1061 page Previous Next First page 上5页 10461047104810491050 下5页 Last page